What are internal factors that can lead to cancer development?

Genetics is a critical internal factor that can lead to cancer development. Variations or mutations in specific genes can predispose individuals to various types of cancer. For instance, inherited mutations in genes such as BRCA1 and BRCA2 are well-known for significantly increasing the risk of breast and ovarian cancers. Unlike external factors, which include environmental influences or lifestyle choices, genetics represents a biological predisposition to cancer. Individuals carry hereditary genetic traits that may express themselves through cellular changes, leading to uncontrolled cell growth and the formation of tumors.

Understanding the role of genetics in cancer is essential for targeted screening, personalized treatment plans, and genetic counseling for those at risk. This internal factor can thus be critical in predicting an individual's likelihood of developing certain cancers and guiding preventive measures.